Biophysics

Download PDF by Didier Chatenay Ph.D.,Simona Cocco Ph.D.,Remi Monasson: Multiple Aspects of DNA and RNA: from Biophysics to

By Didier Chatenay Ph.D.,Simona Cocco Ph.D.,Remi Monasson Ph.D.,Denis Thieffry Ph.D.,Jean Dalibard Ph.D.

ISBN-10: 0444520813

ISBN-13: 9780444520814

ISBN-10: 0444550623

ISBN-13: 9780444550620

This publication is devoted to the a number of points, that's, organic, actual and computational of DNA and RNA molecules. those molecules, principal to important tactics, were experimentally studied by way of molecular biologists for 5 a long time because the discovery of the constitution of DNA through Watson and Crick in 1953. contemporary progresses (e.g. use of DNA chips, manipulations on the unmarried molecule point, availability of big genomic databases...) have published an imperious want for theoretical modelling. additional progresses will essentially now not be attainable with no an built-in figuring out of all DNA and RNA points and studies.

The ebook is meant to be a computing device reference for complicated graduate scholars or younger researchers prepared to procure a extensive interdisciplinary realizing of the a number of facets of DNA and RNA. it truly is divided in 3 major sections:

The first part contains an creation to biochemistry and biology of nucleic acids. The constitution and serve as of DNA are reviewed in R. Lavery's bankruptcy. the following contribution, through V. Fritsch and E. Westhof, concentrates at the folding houses of RNA molecules. The mobile methods related to those molecules are reviewed through J. Kadonaga, with certain emphasis at the law of transcription. those chapters doesn't require any initial wisdom within the box (except that of simple biology and chemistry).

The moment part covers the biophysics of DNA and RNA, beginning with fundamentals in polymer physics within the contribution via R. Khokhlov. a wide area is then dedicated to the presentation of modern experimental and theoretical progresses within the box of unmarried molecule reports. T. Strick's contribution provides a close description of a few of the micro-manipulation thoughts, and studies fresh experiments at the interactions among DNA and proteins (helicases, topoisomerases, ...). The theoretical modeling of unmarried molecules is gifted by means of J. Marko, with a different awareness paid to the elastic and topological houses of DNA. ultimately, advances within the knowing of electrophoresis, a strategy of the most important significance in daily molecular biology, are uncovered in T. Duke's contribution.

The 3rd part offers presents an summary of the most computational techniques to combine, examine and simulate molecular and genetic networks. First, J. van Helden introduces a chain of statistical and computational tools permitting the identity of brief nucleic fragments putatively fascinated with the law of gene expression from units of promoter sequences controlling co-expressed genes. subsequent, the bankruptcy via Samsonova et al. connects this factor of transcriptional law with that of the keep an eye on of mobilephone differentiation and trend formation in the course of embryonic improvement. eventually, H. de Jong and D. Thieffry evaluate a sequence of mathematical methods to version the dynamical behaviour of complicated genetic regulatory networks. This contribution contains short descriptions and references to profitable functions of those methods, together with the paintings of B. Novak, at the dynamical modelling of mobilephone cycle in numerous version organisms, from yeast to mammals.

. offers a accomplished review of the constitution and serve as of DNA and RNA on the interface among physics, biology and knowledge science.

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Multiple Aspects of DNA and RNA: from Biophysics to Bioinformatics: Lecture Notes of the Les Houches Summer School 2004 by Didier Chatenay Ph.D.,Simona Cocco Ph.D.,Remi Monasson Ph.D.,Denis Thieffry Ph.D.,Jean Dalibard Ph.D.


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