Biotransformation and Metabolite Elucidation of Xenobiotics: by Ala F. Nassar PDF

By Ala F. Nassar

ISBN-10: 0470504781

ISBN-13: 9780470504789

The aim of this e-book is to enhance the readers' wisdom of metabolite elucidation in drug metabolism via exposing them to intensive assurance of the biotransformation of xenobiotics, concepts for deciding on and characterizing metabolites, FDA directions, and case experiences on the right way to increase the decision-making strategy in structural amendment of drug applicants to lessen toxicity.

The ebook comprises eight chapters; it first presents an creation on biotransformation of xenobiotics, after which provides glossy ways and techniques for facing metabolite characterization, utilizing instruments reminiscent of LC-MS, H-D alternate, solid isotopes LC-MS-NMR, and radiolabeled compounds. additionally, ideas for facing reactive intermediates in drug discovery and improvement are provided in addition to case reviews on enhancing the decision-making strategy within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of protection trying out of drug metabolites and why, how, and whilst to check their safety.

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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar

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