By Donald Huddler,Edward R. Zartler
Applied Biophysics for Drug Discovery is a advisor to new recommendations and ways to settling on and characterizing small molecules in early drug discovery. Biophysical tools are reasserting their application in drug discovery and during a mix of the increase of fragment-based drug discovery and an elevated specialise in extra nuanced characterisation of small molecule binding, those tools are enjoying an expanding function in discovery campaigns.
This textual content emphasizes useful concerns for choosing and deploying middle biophysical process, together with yet no longer constrained to ITC, SPR, and either ligand-detected and protein-detected NMR.
Topics lined include:
• layout issues in biophysical-based lead screening
• Thermodynamic characterization of protein-compound interactions
• Characterizing pursuits and screening reagents with HDX-MS
• Microscale thermophoresis tools (MST)
• Screening with vulnerable Affinity Chromatography
• how you can determine compound place of abode time
• 1D-NMR tools for hit identification
• Protein-based NMR equipment for SAR development
• case reviews integrating a number of biophysical methods
This textual content is perfect for tutorial investigators and scientists making plans hit characterization campaigns or designing and optimizing screening strategies.
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Extra resources for Applied Biophysics for Drug Discovery
Applied Biophysics for Drug Discovery by Donald Huddler,Edward R. Zartler